The first cases of cholera were detected on 21 October 2016, in the Cape Coast district, Central region when a case- patient presented with acute watery diarrhoea. The next day there were two case-patients with similar symptoms also in Cape Coast district. The number of cases detected in peri-urban communities in Cape Coast Metropolitan have continued to rise from 36 cases on the 26 October, to 117 cases on 30 October. By the 2 November, the total number of cases had risen to 172 with zero deaths. The exponential increase in cases indicates high transmission potential of infections in the peri urban communities.